Left ventricular dysfunction in patients with chronic obstructive pulmonary disease

Abstract

Objective: studying the effects of chronic obstructive pulmonary disease on left ventricle (LV) systolic and diastolic functions. Patients and Methods: A total of 70 cases of diagnosed chronic obstructive pulmonary disease patients (Current smokers or quitters) with 70 age, sex matched healthy control subjects were included in this study. This study was conducted at the Cardiology and pulmonolgy departments in Tishreen University Hospital in Lattakia Syria. All patients with COPD underwent for 2D Echocardiography and the same was done for the controls. . Results: We note a decrease in the mean values of the left ventricular ejection fraction (LVEF) in patients (53.85±6.5) compared to the controls (63.12 ± 4.1%) with (P<0.05). And within the group of cases, it was decreasing with the increasing stage of COPD. Diastolic dysfunction was noticed in patients with COPD. In patients, there was a statistically significant increase in IVRT [ 93.87±12.4 ms] VS.[ 77.49±1.6 ms] in control group (P<0.05) and it is increasing with the increasing stage of COPD. We noticed a statistically significant increase in Myocardial Performance Index(MPI) in COPD patients [0.49±0.05] VS. [0.37±0.01] in control group (P<0.05) and also increases with the increasing stage of COPD. Conclusion: In patients with chronic obstructive pulmonary disease, LV systolic function decreases, LV diastolic dysfunction increases and MPI also increases which reflect both systolic and diastolic LV dysfunction and both of them increases with increasing stage of COPD.